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Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays.
J Proteome Res
March 2025
BU Target Discovery & Proteomics Laboratory (BU-TDPL), Boston University, Boston, Massachusetts 02215, United States.
Uncompetitive inhibition is an effective strategy for suppressing dysregulated enzymes and their substrates, but discovery of suitable ligands depends on often-unavailable structural knowledge and serendipity. Hence, despite surging interest in mass spectrometry-based target identification, proteomic studies of substrate-dependent target engagement remain sparse. Herein, we describe a strategy for the discovery of substrate-dependent ligand binding.
View Article and Find Full Text PDFRational Design of Near-Infrared Reflective Pigments by Adjusting the Ni Coordination Environment.
Inorg Chem
March 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China.
Inorganic pigments offer excellent potential because of their resilience in a variety of environments, and high-reflectance near-infrared (NIR) pigments are a useful tactic to reduce the heat island effect. Nonetheless, the design of inorganic pigments is still dominated by serendipity, and it has never been easy to come up with logical designs for NIR reflective inorganic pigments. By modifying the coordination environment of Ni using the generic formulas LiMgNiPO and LiZnNiPO ( = 0.
View Article and Find Full Text PDFNew perspectives on repetitive behaviour.
Psychol Res
March 2025
Leeds Business School, Leeds Beckett University, Leeds, LS1 3HL, UK.
Human existence is shaped by interconnected patterns and repetitions that unfold in rhythmic cycles, from biological functions to socially constructed behaviors. While innate (physiological) and natural (environmental) cycles remain fixed, self-constructed cycles, such as routines and habits, are more dynamic, shaped by human agency. These repetitive behaviors often enhance efficiency, goal achievement, well-being, and stress reduction.
View Article and Find Full Text PDFIn recent years, data-driven stories have found a firm footing in journalism, business, and education. They leverage visualization and storytelling to convey information to broader audiences. Likewise, immersive technologies, like augmented and virtual reality devices, provide excellent potential for exploring and explaining data, thus inviting research on how data-driven storytelling transfers to immersive environments.
View Article and Find Full Text PDFFrom Rat Tails to Glycoproteostasis: Motivated by Biology, Enabled by Biophysics, and Lucky.
J Mol Biol
February 2025
Departments of Biochemistry & Molecular Biology and Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address:
In this article I tell the story of my career path and how I have come to focus my research on protein folding in the cell. My early fascination with protein folding began during my undergraduate research. My graduate work exploited reductionist approaches to explore structural features in proteins by using cyclic peptide models ofβ-turns.
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