Background: Hydrogen peroxide (HO) has been used for more than a century clinically to control plaque and gingival inflammation, with unclear supporting evidence.
Aim: The aim of the present systematic review of the literature is to assess the effect of mouth rinses with HO on dental plaque, gingival inflammation, and oral microorganisms.
Methods: Five databases (PubMed, Scopus, Embase, Cochrane Library, and Web of Science) were searched with the following focused question: what is the effect of hydrogen peroxide, in comparison to chlorhexidine or to a placebo solution, in oral microbiota control, dental plaque, and gingival inflammatory outcomes? Two independent examiners retrieved the articles and evaluated the evidence.
Results: The majority of included studies were performed with 1.5% HO. Results related to plaque accumulation generally demonstrate a slightly better effect of HO as compared to placebo mouth rinses, however with a lower performance as compared to chlorhexidine. In terms of gingival inflammation, HO performs better than placebo and more clearly demonstrates an anti-inflammation effect. No studies evaluated the effect of HO against viruses or fungi. In terms of bacteria, HO demonstrates an antibacterial effect.
Conclusion: Rinsing with HO has the potential to affect plaque, gingivitis, and oral bacteria, as compared to placebo. However, the antibacterial results are not comparable to the performance of chlorhexidine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648695 | PMC |
| http://dx.doi.org/10.1155/2020/8841722 | DOI Listing |
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