AI Article Synopsis
- Human urine, once thought to be sterile, has revealed a complex microbiota through culturomics that focused on anaerobic bacteria, isolating 450 species from 435 samples.
- The study identified 256 bacteria not previously described in urine, including 18 new species, with 35% of the isolated species being anaerobes.
- Findings indicate a significant overlap between urinary microbiota and gut microbiota, suggesting that many urinary bacteria originate from the gut, prompting a re-evaluation of our understanding of urinary health.
Article Abstract
Human urine was considered sterile for a long time. However, 416 species have been previously cultured, including only 40 anaerobic species. Here, we used culturomics, particularly those targeting anaerobes, to better understand the urinary microbiota. By testing 435 urine samples, we isolated 450 different bacterial species, including 256 never described in urine of which 18 were new species. Among the bacterial species identified, 161 were anaerobes (35%). This study increased the known urine repertoire by 39%. Among the 672 bacterial species isolated now at least once from urine microbiota, 431 (64.1%) were previously isolated from gut microbiota, while only 213 (31.7%) were previously isolated from vagina. These results suggest that many members of the microbiota in the urinary tract are in fact derived from the gut, and a paradigm shift is thus needed in our understanding.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596177 | PMC |
| http://dx.doi.org/10.3389/fmicb.2020.513305 | DOI Listing |
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