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Hypothermia for neuroprotection in adults after cardiac arrest.
Cochrane Database Syst Rev
May 2023
Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Background: Good neurological outcome after cardiac arrest is difficult to achieve. Interventions during the resuscitation phase and treatment within the first hours after the event are critical for a favourable prognosis. Experimental evidence suggests that therapeutic hypothermia is beneficial, and several clinical studies on this topic have been published.
View Article and Find Full Text PDFThe hypokalaemia that came from the cold.
Clin Kidney J
May 2023
Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, USA.
While electrolyte disorders are common in nephrologists' clinical practice, hypothermia is a condition that nephrologists rarely encounter. Hypothermia can induce several pathophysiological effects on the human body, including hypokalaemia, which is reversible with rewarming. Despite growing evidence from animal research and human studies, the underlying mechanisms of hypothermia-induced hypokalaemia remain unclear.
View Article and Find Full Text PDFThe proarrhythmic effects of hypothermia in atria isolated from 5-HT-receptor-overexpressing mice.
Eur J Pharmacol
September 2021
Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany. Electronic address:
We investigated whether hypothermia would be arrhythmogenic in mice that overexpress the human 5-HT receptor only in their cardiac myocytes (5-HT-TG). Contractile studies were performed in isolated, electrically driven (1 Hz) left and spontaneously beating right atrial preparations of 5-HT-TG and littermate wild-type control mice (WT). Hypothermia (23 °C) decreased the force of contraction in the mouse right and left atrial preparations.
View Article and Find Full Text PDFHypothermia-Induced Hypokalemia.
Am J Med
May 2021
Department of Medicine, Oregon Health and Science University, Portland, Ore. Electronic address:
Cold fluids for induction of targeted temperature management: A sub-study of the TTH48 trial.
Resuscitation
March 2020
Department of Anesthesiology, Intensive Care and Paine Medicine, University of Helsinki and Helsinki University Hospital, Finland; Department of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Finland. Electronic address:
Background: Pre-intensive care unit (ICU) induction of targeted temperature management (TTM) with cold intravenous (i.v.) fluids does not appear to improve outcomes after in out-of-hospital cardiac arrest (OHCA).
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