Visible-Light-Induced Regio- and Stereoselective C(sp)-H Trifluoroethylation of Enamides with 2,2,2-Trifluoroethyl Iodide.

Org Lett

Institute of Advanced Synthesis, Technical Institute of Fluorochemistry, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.

Published: November 2020

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.0c03418DOI Listing

Publication Analysis

Top Keywords

regio- stereoselective
8
222-trifluoroethyl iodide
8
visible-light-induced regio-
4
stereoselective csp-h
4
csp-h trifluoroethylation
4
trifluoroethylation enamides
4
enamides 222-trifluoroethyl
4
iodide photoredox-catalyzed
4
photoredox-catalyzed regio-
4
stereoselective trifluoroethylation
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!