Pseudomelanosis Duodeni.

N Engl J Med

Calvary Mater Hospital, Newcastle, NSW, Australia

Published: November 2020

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http://dx.doi.org/10.1056/NEJMicm2001352DOI Listing

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Article Synopsis
  • Pseudomelanosis duodeni (PD) is a rare but benign condition characterized by dark speckles in the proximal duodenum, often linked to chronic diseases and certain medications, notably oral iron supplements.
  • A 56-year-old woman with iron-deficiency anemia and a history of peptic ulcers was diagnosed with PD after an endoscopy revealed suspicious findings, confirmed by pathology showing iron-containing macrophages.
  • The case highlights the connection between oral iron therapy and PD development, suggesting further research is needed on long-term outcomes and management strategies for this condition.
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A rare case of pseudomelanosis duodeni.

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July 2024

Department of Gastroenterology, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China. Electronic address:

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Pseudomelanosis of the duodenum and stomach.

Arab J Gastroenterol

August 2024

Emirates Health Services, United Arab Emirates. Electronic address:

Pseudomelanosis duodeni is characterized by endoscopic findings of black or black-brown speckled pigmentation in the duodenal mucosa, usually diagnosed via biopsy. This report presents a case of a 75-year-old male presented with left lower abdominal pain, change in bowel habits, and decreased appetite. Gastroduodenoscopy and biopsies of the duodenum and antrum lead to the diagnosis of pseudomelanosis duodeni.

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