Occupational exposures to dust with elevated levels of respirable crystalline silica in artificial stone increase workers' risk for silicosis.
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Burden of silicosis based on the Global Burden of Disease Study 2021: trend analysis of incidence, mortality, and disability-adjusted life years, and projections for the next 30 years.
J Thorac Dis
February 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Shihezi University, Shihezi, China.
Background: Silicosis, an occupational disease caused by chronic silica exposure, has a high global burden and limited treatment options. This study analyzed the epidemiological trends and future projections of silicosis based on data from the Global Burden of Disease (GBD), aiming to provide data support for public health interventions.
Methods: We extracted and analyzed the data on the incidence, mortality, and disability-adjusted life years (DALYs) of silicosis, as well as the age-standardized rate (ASR) of silicosis from the GBD Study 2021.
Silicosis related pleural effusion: black spots in pleura.
BMJ Case Rep
March 2025
Department of Radiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
A male patient in his 70s, who had previously worked as a bricklayer, presented with worsening shortness of breath on exertion and cough for 6 months. He had lost weight, and a respiratory examination suggested a right pleural effusion. Routine evaluation was unremarkable.
View Article and Find Full Text PDFPuerarin alleviates silicon dioxide-induced pulmonary inflammation and fibrosis via improving Autophagolysosomal dysfunction in alveolar macrophages of murine mice.
Int Immunopharmacol
March 2025
School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province 063210, PR China; Hebei Key Laboratory for Organ Fibrosis, North China University of Science and Technology, Tangshan, Hebei Province 063210, PR China; Hebei Coordinated Innovation Center of Occupational Health and Safety, North China University of Science and Technology, Tangshan, Hebei Province 063210, PR China. Electronic address:
Silicosis, caused by the inhalation of silicon dioxide (SiO), is one of the most pressing public health problems. Nevertheless, there is currently no effective treatment. This study employed male C57BL/6 J mice and mouse alveolar macrophage cell line MH-S to investigate the biological mechanism in the development of silicosis, with a view to exploring the potential applications of puerarin (Pue) in the improvement of pulmonary inflammation and fibrosis in SiO-exposed mice.
View Article and Find Full Text PDFA Nomogram for Predicting Pulmonary Embolism in Silicosis Patients.
Clin Respir J
March 2025
Department of Respiratory Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Background: As one of the most severe occupational diseases that prevention efforts have supported for several decades, silicosis is still a public health issue that lacks a prediction model for pulmonary embolism.
Methods: A total of 162 patients confirmed to have silicosis were all involved in a training cohort to construct a nomogram with the outcome diagnosed by the CTPA using logistic regression. Univariate and LASSO analyses were used to select variables for the nomogram.
Rapid, Non-Invasive Breath Analysis for Enhancing Detection of Silicosis Using Mass Spectrometry and Interpretable Machine Learning.
J Breath Res
March 2025
School of Chemistry, University of New South Wales, UNSW Sydney, School of Chemistry, Sydney, New South Wales, 2052, AUSTRALIA.
Occupational lung diseases, such as silicosis, are a significant global health concern, especially with increasing exposure to engineered stone dust. Early detection of silicosis is helpful for preventing disease progression, but existing diagnostic methods, including X-rays, computed tomography scans, and spirometry, often detect the disease only at late stages. This study investigates a rapid, non-invasive diagnostic approach using atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) to analyse volatile organic compounds (VOCs) in exhaled breath from 31 silicosis patients and 60 healthy controls.
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