Purpose: To assess the gender roles and behavioral outcomes in children with 21-hydroxylase deficiency (21-OHD) in Southern China.
Methods: A total of 50 individuals with 21-OHD participated in our study, (30 boys and 20 girls), as well as another 19 age-matched non-affected relatives of patients (12 boys and 7 girls). Psychological adjustment was assessed with a preschool activity survey and a Conner parent symptom questionnaire was modified for retrospective reporting.
Results: The response rate of the questionnaire in the control group was only 36.5%. All the patients were diagnosed with salt-wasting of 21-OHD. Our study revealed that the masculine score was higher in male patients with 21-OHD than male controls and female patients. Compared with that in the female 21-OHD patient group, the masculine score in the female control group was lower, while comparative masculinization was found in the male controls. Regarding behavioral problems, there was a higher incidence of parent-reported problems among children with 21-OHD than controls, including conduct problems, impulsive hyperactivity, anxiety, and hyperactivity index.
Conclusion: Parents of 21-OHD patients in Southern China were unwilling to disclose the condition of their children to the society. Masculinization and behavioral problems were prevalent among patients with 21-OHD, which highlighted the importance of psychological and social support for 21-OHD patients and their families.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.steroids.2020.108754 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors.
Front Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFTranslation and Adaptation of the SCOFF Questionnaire to the Greek Language (G-SCOFF) Using a Tertiary-Setting Adolescent Sample.
Nutrients
January 2025
Department of Nutrition, General Hospital of Thessaloniki "G. Gennimatas", 41 Ethnikis Aminis Str., GR-54635 Thessaloniki, Greece.
Background/objectives: Feeding and eating disorders (FEDs) constitute an important mental health problem today, especially among youngsters. The Sick, Control, One, Fat, Food (SCOFF) questionnaire was developed 25 years ago and remains the most frequently applied screening tool for FEDs among adults and youngsters. The aim of the present study was to translate and adapt the SCOFF questionnaire to the Greek language, using a tertiary-setting adolescent sample.
View Article and Find Full Text PDFCross-Sectional Study on the Influence of Religion on the Consumption of Ultra-Processed Food in Spanish Schoolchildren in North Africa.
Nutrients
January 2025
HUM-613 Research Group, Department of Inorganic Chemistry, Faculty of Health Sciences, Melilla Campus, University of Granada, C/Santander s/n, 52005 Melilla, Spain.
(1) Background: The consumption of ultra-processed foods (UPFs) constitutes a public health problem given their high availability and easy accessibility among children and young people and their influence on the development of non-communicable diseases in the long term. In this context, culture and religion may be modulating factors for the consumption of processed food. The aim of this study is to assess the consumption of UPFs in Spanish schoolchildren living in Melilla (North Africa), together with the possible impact of religion on this.
View Article and Find Full Text PDFExamining the Prevalence, Characteristics, and Potential Links Between Skin Disorders and Autism Spectrum Disorder (ASD).
J Clin Med
January 2025
Autism Research and Treatment Center, Department of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Increasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality of life, and they have an impact on social isolation, behavioral problems, cognitive scores, and some subscales of ASD. This study was an online questionnaire-based, observational, and cross-sectional study conducted during the period from August 2022 through January 2023 to examine dermatological manifestations among ASD individuals compared to controls.
View Article and Find Full Text PDFEffect of Gradient Transition Layer on the Cracking Behavior of Ni60B (NiCrBSi) Coatings by Laser Cladding.
Materials (Basel)
January 2025
State Key Laboratory of High-Performance Precision Manufacturing, Dalian University of Technology, Dalian 116024, China.
Laser cladding technology is an effective method for producing wear-resistant coatings on damaged substrates, improving both wear and corrosion resistance, which extends the service life of components. However, the fabrication of hard and brittle materials is highly susceptible to the problem of cracking. Using gradient transition layers is an effective strategy to mitigate the challenge of achieving crack-free laser-melted wear-resistant coatings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!