During a chemical investigation of , three new [wikstrocins A-C (-)] and three known tigliane diterpenoids (-) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds ( and ) showed potent anti-HIV activity with IC values of 3.8 and 12.8 nM, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176626 | PMC |
| http://dx.doi.org/10.1021/acs.jnatprod.0c00700 | DOI Listing |
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