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Optimal Recovery of Valuable Biomaterials, Chondroitin Sulfate and Bioapatites, from Central Skeleton Wastes of Blue Shark. | LitMetric

Optimal Recovery of Valuable Biomaterials, Chondroitin Sulfate and Bioapatites, from Central Skeleton Wastes of Blue Shark.

Polymers (Basel)

Group of Recycling and Valorisation of Waste Materials (REVAL), Marine Research Institute (IIM-CSIC), Eduardo Cabello, 6. Vigo, 36208 Galicia, Spain.

Published: November 2020

AI Article Synopsis

  • The study focuses on optimizing the hydrolysis process of blue shark skeletons, which are usually discarded as waste after filleting, to produce chondroitin sulfate (CS) and recover valuable bioapatites.
  • A specific chemical treatment and purification method successfully yielded glycosaminoglycan with a high purity of 97% and a productive yield of 2.8%.
  • The findings suggest that the mineralized tissues of blue sharks can be a valuable, untapped source for high-value biomaterials with potential uses in bone and tissue regeneration.

Article Abstract

The industrial filleting of blue shark () led to the generation of a large number of central skeletons of low interest to fishmeal plants handling such wastes. In this context, the present study describes the optimization of the hydrolysis process (pH 8.35, T 58 °C, 1% () of alcalase and t = 4 h) to produce chondroitin sulfate (CS) together with the recovery of bioapatites. Then, that hydrolysate was chemically treated with an optimal alkaline-hydroalcoholic-saline solution (0.48 M of NaOH, 1.07 volumes of EtOH and 2.5 g/L of NaCl) and finally purified by ultrafiltration-diafiltration (30 kDa) to obtain glycosaminoglycan with a purity of 97% and a productive yield of 2.8% (/ of skeleton). The size of the biopolymer (CS) was of 58 kDa with prevalence of 6S-GalNAc sulfation (4S/6S ratio of 0.25), 12% of GlcA 2S-GalNAc 6S and 6% of non-sulfated disaccharides. Crude bioapatites were purified by pyrolysis and FT-Raman and XRD techniques confirm the presence of hydroxyapatite [Ca(PO)(OH)], with a molar mass of 502.3 g/mol, embedded in the organic matrix of the skeleton. The mineralized tissues of blue shark are promising marine sources for the extraction of high value biomaterials with clinical application in bone and tissue regeneration and are still completely unexplored.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694617PMC
http://dx.doi.org/10.3390/polym12112613DOI Listing

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