Connexins are membrane-spanning proteins that form membrane channels and hemichannels. They are involved in the cellular communication and in the maintenance of tissue homeostasis. Recent studies in humans and animals have demonstrated that the expression and distribution of Cx43, the most studied connexin, can change during aging. However, the research on the involvement of the other connexins in cardiac and hepatic aging is, at present, still very poor. Hence, the aim of this study is to evaluate the expression of Cx43 and Cx26 in the heart as well as Cx26 and Cx32 in the liver of a rat model that aged naturally, rather than prematurely because of genetic mutations or age-related diseases. The results obtained in the present study have demonstrated that these connexins decrease in rat cardiomyocytes and in rat hepatocytes as they age. This change was revealed only at protein level, as connexin-mRNAs remained unchanged during aging. Moreover, the aged rats showed an increase in body fat, whose subcutaneous layer tended to be higher. Finally, how these changes could represent signs of physiological adaptation in successful aging was discussed.
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http://dx.doi.org/10.1016/j.acthis.2020.151651 | DOI Listing |
Psychopharmacology (Berl)
December 2024
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Rationale: Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in working memory, and post-mortem data has found disruptions of H3R expression in schizophrenia.
Objectives: We examined the role of H3R in vivo to elucidate its role on working memory impairment in schizophrenia.
Arch Public Health
December 2024
Panzhihua Central Hospital, Panzhihua, China.
Background: At present, China's elderly population is facing several difficulties. The implementation of active aging is an important initiative in the face of the rapidly developing situation of population aging, among which improving elderly expectations regarding the aging level is the key link to achieving active aging. Improving the quality of life of the majority of elderly individuals is the main goal of active aging.
View Article and Find Full Text PDFDig Liver Dis
December 2024
Hospital Universitario del Tajo, Critical Care, Department, Universidad Alfonso X el Sabio, Spain. Electronic address:
Background: Gastrointestinal endoscopy is increasingly performed under sedation in older patients. Aging has implications in increasing the morbidity and the risk of complications related to sedation. The aim of this study is to assess the difference in complications between patients aged 65 to 74 years and those aged over 75 years.
View Article and Find Full Text PDFJ Epidemiol
December 2024
Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology.
Background: Community social capital is associated with various health outcomes; however, its impact on mortality is not fully understood, particularly in non-Western settings. This study examined the association between community-level social capital and all-cause mortality among community-dwelling older Japanese adults.
Methods: The baseline data were obtained from a 2015 questionnaire survey for all 132,005 residents aged ≥65 years without long-term care insurance certification in Adachi Ward (consisting of 262 small districts) of the Tokyo metropolitan area.
Nihon Koshu Eisei Zasshi
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Research Team for Social Participation and Healthy Aging.
Objective This study examined the factors associated with the status of group activities provided to older adults during the COVID-19 pandemic by community groups aiming to improve the health and social interactions of older adults. Methods A mail survey was conducted with 372 leaders of neighborhood associations and Senior Citizen Clubs in November 2020 in Ward A, Tokyo. The questionnaire asked leaders about the status of group activities provided by neighborhood associations and the aforementioned clubs for older adults.
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