AI Article Synopsis
- - Atrial fibrillation (AF) is a frequent heart rhythm disorder, especially seen in patients after cardiac surgery, but the role of mitochondrial genetics in this condition is still unclear.
- - Researchers studied mitochrondrial DNA from 78 heart samples, categorizing them into three groups based on their AF status before and after surgery.
- - Results indicated that haplogroup H may protect against permanent AF, while haplogroup U may increase the risk, and there was more mitochondrial DNA in patients who had AF post-surgery compared to those who didn't.
Article Abstract
Atrial fibrillation (AF) is a common arrhythmia in the general population and following cardiac surgery. The influence of mitochondrial genomics on AF pathogenesis is not fully understood. We analyzed mitochondrial variables from 78 human atrial samples collected from cardiac surgeries in the following groups: 1) permanent preoperative AF; 2) preoperative sinus rhythm (SR) with postoperative AF; and 3) pre-/postoperative SR. Haplogroup H appeared offer protection against, and haplogroup U predispose to permanent AF. mtDNA content was higher in group 2 than in 3. These findings contribute to a better understanding of the influence of mitochondria on AF pathogenesis.
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| http://dx.doi.org/10.1016/j.mito.2020.11.007 | DOI Listing |
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