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Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery. | LitMetric

Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery.

Blood Adv

Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Sart-Tilman, Liège, Belgium.

Published: November 2020

AI Article Synopsis

  • HBZ RNA stops the normal process that helps make proteins from the human T-cell leukemia virus type 1.
  • This disruption can help the virus hide and not be noticed by the body's immune system.
  • It might allow the virus to stay asleep in the body without causing illness right away.

Article Abstract

By disrupting basal transcription machinery, HBZ RNA inhibits sense transcription of human T-cell leukemia virus type 1. Repression of genomic expression may allow entry into proviral latency and escape from immune response.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656924PMC
http://dx.doi.org/10.1182/bloodadvances.2020001675DOI Listing

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