A rhodium-catalyzed C-H amidation/cyclization sequence provides benzothiadiazine-1-oxides from sulfoximines and 1,4,2-dioxazol-5-ones in good yields. The reaction is characterized by a high functional group tolerance and, in contrast to most previous transformations of this type, is well-suited for alkyl--aryl-substituted sulfoximines.
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Construction of Axially Chiral Dialdehydes via Rhodium-Catalyzed Enantioselective C-H Amidation.
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Anhui Normal University, School of Chemistry and Materials Science, 189 Jiuhua South Road, 241002, Wuhu, CHINA.
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Pfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, California 92121, United States.
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