AI Article Synopsis
- - A case study details a 17-year-old female with linear porokeratosis, a skin condition characterized by abnormal keratinization and bone resorption, showing significant improvement with a treatment of 2% cholesterol/2% lovastatin ointment.
- - Porokeratosis involves a skin layer (cornoid lamella) that includes incorrectly matured cells and can arise from mutations in the mevalonate pathway, suggesting a complex genetic basis for the disorder.
- - This is one of the few cases documenting bone resorption related to linear porokeratosis, with only one previous case reported involving a distal digit.
Article Abstract
We describe a case of linear porokeratosis with associated bone resorption in a 17-year-old female with marked improvement after 2% cholesterol/2% lovastatin ointment application. Porokeratosis is a heterogenous group of keratinization disorders characterized by a cornoid lamella, consisting of focal dyskeratotic cells in the granular layer and columns of parakeratosis. The pathogenesis of porokeratosis is not fully elucidated; however, germline mutations have recently been identified in the mevalonate pathway which can lead to a buildup of metabolites that could play a role in dysmaturation. There has only been one prior report of an affected distal digit with underlying bone resorption in association with linear porokeratosis.
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| http://dx.doi.org/10.1111/pde.14447 | DOI Listing |
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