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Unlabelled: Mild hypoxic-ischemic encephalopathy is common in neonates with no evidence-based therapies, and 30-40% of patients experience adverse outcomes. The nature and progression of mild injury is poorly understood. Thus, we studied the evolution of mild perinatal brain injury using longitudinal two-photon imaging of transgenic fluorescent proteins as a novel readout of neuronal viability and activity at cellular resolution.
View Article and Find Full Text PDFBackground: People with Alzheimer's disease (AD) exhibit varying clinical trajectories. There is a need to predict future AD-related outcomes such as morbidity and mortality using clinical profile at the point of care.
Objective: To stratify AD patients based on baseline clinical profiles (up to two years prior to AD diagnosis) and update the model after AD diagnosis to prognosticate future AD-related outcomes.
The Linear Retrograde Infiltration (LiRi) Technique for Buttock Fat Infiltration: A Cohort Evolution.
Aesthet Surg J
January 2025
Plastic surgeon in private practice, Guadalajara, México.
Background: Autologous fat grafting in the buttocks has gained great popularity However, one of the main risks is infiltration of fat into the systemic venous system, leading to potential complications such as macroscopic fatty embolism (MAFE), which can be fatal.
Objectives: This study evaluated the safety and efficacy of the LiRi (Linear Retrograde infiltration) for autologous fat grafting in the buttocks, and its evolution over a six-month follow-up period.
Methods: The procedure was performed in 114 patients.
Population Genomics of Japanese Macaques (Macaca fuscata): Insights into Deep Population Divergence and Multiple Merging Histories.
Genome Biol Evol
January 2025
Faculty of Information Science and Technology, Hokkaido University, Kita-14, Nishi-9, Kita-ku, Sapporo, Hokkaido, Japan 060-0814.
The influence of long-term climatic changes such as glacial cycles on the history of living organisms has been a subject of research for decades, but the detailed population dynamics during the environmental fluctuations and their effects on genetic diversity and genetic load are not well understood on a genome-wide scale. The Japanese macaque (Macaca fuscata) is a unique primate adapted to the cold environments of the Japanese archipelago. Despite of the past intensive research for the Japanese macaque population genetics, the genetic background of Japanese macaques at the whole-genome level has been limited to a few individuals, and the comprehensive demographic history and genetic differentiation of Japanese macaques have been underexplored.
View Article and Find Full Text PDFTermination-acidity tailoring of molybdenum carbides for alkaline hydrogen evolution reaction.
Nat Commun
January 2025
i-lab, Vacuum Interconnected Nanotech Workstation (Nano-X), Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China.
Transition-metal carbides have been advocated as the promising alternatives to noble-metal platinum-based catalysts in electrocatalytic hydrogen evolution reaction over half a century. However, the effectiveness of transition-metal carbides catalyzing hydrogen evolution in high-pH electrolyte is severely compromised due to the lowered proton activity and intractable alkaline-leaching issue of transition-metal centers. Herein, on the basis of validation of molybdenum-carbide model-catalyst system by taking advantage of surface science techniques, MoC micro-size spheres terminated by Al doped MoO layer exhibit a notable performance of alkaline hydrogen evolution with a near-zero onset-potential, a low overpotential (40 mV) at a typical current density of 10 mA/cm, and a small Tafel slope (45 mV/dec), as well as a long-term stability for continuous hydrogen production over 200 h.
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