AI Article Synopsis
- Recent research has focused on developing new tacrine analogues to treat Alzheimer's disease, as the original tacrine was withdrawn due to its side effects, particularly liver toxicity.
- While tacrine offered limited cognitive benefits, the goal is now to create safer alternatives that do not have hepatotoxicity.
- Additionally, there is a push to design multitarget tacrines that can simultaneously inhibit cholinesterase and affect other biological pathways related to Alzheimer's.
Article Abstract
Herein we have reviewed our recent developments for the identification of new tacrine analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor approved for AD treatment, did not stop the progression of AD, producing only some cognitive improvements, but exhibited secondary effects mainly due to its hepatotoxicity. Thus, the drug was withdrawn from the clinics administration. Since then, many publications have described non-hepatotoxic tacrines, and in addition, important efforts have been made to design multitarget tacrines by combining their cholinesterase inhibition profile with the modulation of other biological targets involved in AD.
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| http://dx.doi.org/10.1002/tcr.202000107 | DOI Listing |
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