Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic inflammation. The aim of this study was to assess calprotectin expression levels in a mouse model of asthma, and to observe the relationship of serum calprotectin level and clinical variables in patients with asthma.
Methods: Mice were sensitized and challenged with 10 μg and 20 μg of , respectively; mice treated with saline were used as a control. The levels of calprotectin were determined using enzyme-linked immunosorbent assay, immunoblotting, and immunohistochemical analysis. The serum levels of calprotectin were also assessed in patients with asthma. The relationship between calprotectin and clinicopathological characteristics was determined.
Results: Calprotectin, S100A8, and S100A9 expression was elevated in the mouse lungs, calprotectin levels were higher in the serum of patients with asthma (n = 33) compared with those of healthy individuals (n = 28). Calprotectin levels correlated with forced expiratory volume in one second/forced vital capacity ( = -0.215, = 0.043), smoke amount ( = 0.413, = 0.017), body mass index ( = -0.445, = 0.000), and blood neutrophil percentage ( = 0.300, = 0.004) in patients with asthma.
Conclusion: Our data suggest that calprotectin could potentially be used as a biomarker for asthma.
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| http://dx.doi.org/10.3346/jkms.2020.35.e362 | DOI Listing |
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