AI Article Synopsis
- Researchers aimed to analyze how estimated glomerular filtration rate (eGFR) changes over time in youth diagnosed with type 1 and type 2 diabetes.
- The study involved a longitudinal assessment of eGFR changes among participants, concluding that a significant percentage experienced eGFR decline, with various factors influencing this change.
- Ultimately, the findings indicated that declines in eGFR are more frequent in type 1 diabetes, while increases are more typical in type 2 diabetes, highlighting the differing impacts of these diabetes types on kidney function over time.
Article Abstract
Aims: We sought to characterize the direction and associated factors of eGFR change following diagnosis of youth-onset type 1 and type 2 diabetes.
Methods: We assessed the direction of eGFR change at two visits (mean 6.6 years apart) in SEARCH, a longitudinal cohort study of youth-onset type 1 and type 2 diabetes. We used the CKiD equation to estimate GFR and categorized 'rising' and 'declining' eGFR as an annual change of ≥3 ml/min/1.73 m in either direction. Multivariable logistic regression evaluated factors associated with directional change in eGFR.
Results: Estimated GFR declined in 23.8% and rose in 2.8% of participants with type 1 diabetes (N = 1225; baseline age 11.4 years), and declined in 18.1% and rose in 15.6% of participants with type 2 diabetes (N = 160; baseline age 15.0 years). Factors associated with rising and declining eGFR (versus stable) in both type 1 and type 2 diabetes included sex, age at diagnosis, baseline eGFR and difference in fasting glucose between study visits. Additional factors in type 1 diabetes included time from baseline visit, HbA1c and body mass index.
Conclusions: Over the first decade of diabetes, eGFR decline is more common in type 1 diabetes whereas eGFR rise is more common in type 2 diabetes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855388 | PMC |
| http://dx.doi.org/10.1016/j.jdiacomp.2020.107768 | DOI Listing |
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