AI Article Synopsis
- A study was conducted on five ligands and fifteen silver(I) complexes, characterized using single crystal X-ray diffraction and various spectroscopic methods.
- The antibacterial and antioxidant activities of these complexes were assessed, revealing that some exhibited greater efficacy than the standard ciprofloxacin and ascorbic acid.
- Binding studies indicated that the complexes interacted with CT-DNA through intercalation and with BSA predominantly via static quenching.
Article Abstract
Synthesis and spectroscopic characterization of five ligands ((E)-2-((pyridin-2-ylmethylene)amino)phenol L1, 2-(pyridin-2-yl)benzo[d]thiazole L2, (E)-N-(2-fluorophenyl)-1-(pyridin-2-yl)methanimine L3, (E)-1-(pyridin-2-yl)-N-(p-tolyl)methanimine L4 and (E)-1-(pyridin-2-yl)-N-(thiophen-2-ylmethyl)methanimine L5 along with fifteen silver(I) complexes of L1 - L5, with a general formula [AgL]X (L = Schiff base and X = NO, ClO or CFSO) is reported. The structures of complexes [Ag(L4)]NO, [Ag(L5)]NO, [Ag(L3)]ClO, [Ag(L4)]ClO and [Ag(L5)]CFSO were determined unequivocally by single crystal X-ray diffraction analysis. Calf-thymus deoxyribonucleic acid (CT-DNA), bovine serum albumin (BSA) binding studies, antioxidant, and antibacterial studies were performed for all complexes. Complexes [Ag(L2)]NO, [Ag(L5)]NO, [Ag(L1)]ClO and [Ag(L3)]ClO whose ligands have an OH and F as substituents or with a thiophene or thiazole moiety showed better antibacterial activities with lower minimum inhibitory concentration (MIC) values compared to the standard ciprofloxacin, against most of the bacterial strains tested. Similarly, complexes [Ag(L1)]NO[Ag(L2)]NO[Ag(L3)]NO and [Ag(L5)]NO with the NO anion, [Ag(L1)]ClO and [Ag(L2)]ClO with ClO anion, and [Ag(L5)]CFSO with CFSO anion showed higher activities for antioxidant studies. Complexes [Ag(L4)]ClO and [Ag(L4)]CFSO with the Methyl substituent and CFSO as the anion, displayed high antioxidant activities in FRAP (ferric reducing antioxidant power) than the standard ascorbic acid. Spectroscopic studies of all the complexes revealed their moderate to high interaction with calf thymus DNA via an intercalation mode. In addition, the relatively moderate interaction of most of the complexes with BSA was through a static quenching mechanism.
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| http://dx.doi.org/10.1016/j.jinorgbio.2020.111266 | DOI Listing |
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