Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
The development of modular strategies for programming self-assembled supramolecular architectures with distinct structural and functional features is of immense scientific interest. We reported on the intrinsic antibacterial capability of anionic amphiphilic gold nanoclusters (GNCs) capped by -mercaptobenzoic acid, which was closely related to the protonation level of terminal carboxylate groups. By using of the metal-ligand coordination-driven and solvent evaporation-induced self-assembly, we constructed GNCs-based mixed-metal metal-organic network (MM-MON) films on titanium disks as antibacterial nanocoatings. Taking the reasonable utilization of tetravalent metal ions M (Ti, Zr, Hf; hard Lewis acid) and bactericidal divalent metal ions M (Cu, Zn; borderline acid) co-incorporated metal-carboxylate coordination bonds, the MM-MON films exhibited superior stability due to the robust M-O bonds and M releasing behavior resulting from the labile M-O coordinating. Together, the MM-MON films integrated the bacteria-responsive character of GNCs, exceptional chemical stability, and greatly enhanced antibacterial activity, ultimately killing adherent bacteria and initiating a self-defensive function. In a rat model for subcutaneous implant-associated infection, the MM-MON nanocoating showed an approximately 2 and 1 log lower multidrug-resistant implant and tissue colonization, respectively. The generalizable modular strategy of the GNC-metal networks is amenable to facilitate the functionalization of metal surfaces for combating implant-associated infections.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1021/acsnano.0c06446 | DOI Listing |
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