AI Article Synopsis
- Previous research indicated that high levels of Forkhead box D4 (FOXD4) in colorectal cancer lead to poor patient outcomes, but further diagnostic and mechanistic studies were lacking.
- This study analyzed FOXD4 expression in colon adenocarcinoma patients using data from The Cancer Genome Atlas and created a nomogram for predicting patient survival based on FOXD4 levels.
- Findings suggest that FOXD4 could serve as a diagnostic biomarker for colorectal cancer, with low expression linked to better clinical outcomes and numerous genes associated with FOXD4 involved in various cancer-related biological processes.
Article Abstract
Previous studies found that Forkhead box D4 () overexpressed in human colorectal cancer had the worst prognosis. However, the diagnostic value and further mechanism have not been fully researched. Statistical examinations for expression colon adenocarcinoma (COAD) patients were obtained from The Cancer Genome Atlas (TCGA). Survival analysis was used to assess its prognostic value. Nomogram model was used for visual prediction of patient survival rate. The online functional enrichment analysis tool was used to evaluate the biological functions and pathways of FOXD4 and its co-expressed genes. Receiver operating characteristic curve analysis suggested that FOXD4 might be a diagnostic biomarker for COAD (<0.001, area under the curve [AUC]=0.728, 95% confidence interval [CI]=0.669-0.787). Low expression of was associated with a good clinical outcome (=0.001, HR=0.517, 95% CI=0.341-0.782). A total of 797 genes were correlated with and associated with cell proliferation, cell differentiation, nuclear matrix, Rap1 signaling pathway, RNA transport, and VEGF signaling pathway. In conclusion, expression of may be a diagnostic and prognostic biomarker in COAD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642708 | PMC |
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