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In transplant medicine, the use of normothermic regional perfusion (NRP) in donation after circulatory determination of death raises ethical difficulties. NRP is objectionable because it restores the donor's circulation, thus invalidating a death declaration based on the permanent cessation of circulation. NRP's defenders respond with arguments that are tortuous and factually inaccurate and depend on introducing extraneous concepts into the law.
View Article and Find Full Text PDFIn this article, we consider the intersection of cognitive motor dissociation (CMD) and artificial intelligence (AI), hence when CMD meets AI. In covert consciousness, there is a discordance between the observed behavior, the traditional bedside mode of assessment, and the response to volitional commands as depicted by neuroimaging or EEG studies. This alphabet soup of acronyms represents both the promise and peril of nascent technology in covert consciousness.
View Article and Find Full Text PDFDataset for the climate-related financial policy index (CRFPI).
Data Brief
June 2023
Chair of Macroeconomics, Faculty of Management and Economics, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Data on the climate-related financial policy index (CRFPI) - comprising the global climate-related financial policies adopted globally and the bindingness of the policy - are provided in this paper for 74 countries from 2000 to 2020. The data include the index values from four statistical models used to calculate the composite index as described in [3]. The four alternative statistical approaches were designed to experiment with alternative weighting assumptions and illustrate how sensitive the proposed index is to changes in the steps followed to construct it.
View Article and Find Full Text PDFPharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes.
Pharmaceutics
December 2022
Institute of Psychology, University of Innsbruck, 6020 Innsbruck, Austria.
Pharmacogenetic variability in drug metabolism leads to patient vulnerability to side effects and to therapeutic failure. Our purpose was to introduce a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in pharmacogenetic subgroups, addressing the concerns of sparse data, incomplete information on phenotypic groups, and heterogeneity of study design. Data on psychotropic drugs metabolized by the cytochrome P450 enzyme CYP2C19 were used as a case study.
View Article and Find Full Text PDFComparing dedicated and designated approaches to integrating task-shared psychological interventions into chronic disease care in South Africa: a three-arm, cluster randomised, multicentre, open-label trial.
Lancet
October 2022
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Background: Community health workers (CHWs) are increasingly providing task-shared psychological interventions for depression and alcohol use in primary health care in low-income and middle-income countries. We aimed to compare the effectiveness of CHWs dedicated to deliver care with CHWs designated to deliver care over and above their existing responsibilities and with treatment as usual for patients with a chronic physical disease.
Methods: We did a three-arm, cluster randomised, multicentre, open-label trial done in 24 primary health-care clinics (clusters) within the Western Cape province of South Africa.
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