AI Article Synopsis
- - Diffuse astrocytoma (WHO grade II) is usually seen as a slow-growing tumor in young adults, but this case shows an early, atypical malignant transformation into a high-grade glioma just 17 months after surgical removal.
- - The patient's tumor showed negative results for IDH 1/2 mutations, which is significant because IDH-wildtype astrocytomas are increasingly recognized for their aggressive behavior.
- - Testing for IDH mutation status is becoming essential for determining the prognosis and guiding treatment decisions for astrocytoma patients.
Article Abstract
Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neucir.2020.09.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!