Accessory pathways are abnormal electrical conductions between the atrial and ventricular myocardium, bypassing the atrioventricular node and as such are an important substrate for arrhythmias. Ablation is a curative treatment and should always be offered to symptomatic patients and asymptomatic patients with high risk professions. Adequate knowledge and understanding of different mapping and ablation techniques is pivotal to achieve successful outcomes.
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http://dx.doi.org/10.1016/j.ccep.2020.09.003 | DOI Listing |
Geroscience
January 2025
Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Background: Superagers, older adults with exceptional cognitive abilities, show preserved brain structure compared to typical older adults. We investigated whether superagers have biologically younger brains based on their structural integrity.
Methods: A cohort of 153 older adults (aged 61-93) was recruited, with 63 classified as superagers based on superior episodic memory and 90 as typical older adults, of whom 64 were followed up after two years.
J Assist Reprod Genet
January 2025
Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Clinical Sciences, Research Group Genetics, Reproduction and Development, Centre for Medical Genetics, Laarbeeklaan 101, 1090, Brussels, Belgium.
Purpose: Primary ovarian insufficiency (POI) is an important cause of female infertility, stemming from follicle dysfunction or premature oocyte depletion. Pathogenic variants in genes such as NOBOX, GDF9, BMP15, and FSHR have been linked to POI. NOBOX, a transcription factor expressed in oocytes and granulosa cells, plays a pivotal role in folliculogenesis.
View Article and Find Full Text PDFSci Rep
January 2025
College of Engineering, Ocean University of China, Qingdao, 266404, China.
Although deterministic analysis can provide initial insights into slope stability, there is no way to reflect the true distribution of soil properties within a slope. To further investigate the effects of the spatial variability of soil properties on the stability and failure mechanism of slope under different foundation types, this study develops a framework combining simple limit equilibrium method (LEM), Monte Carlo Simulation (MCS), and random field to incorporate these factors into slope probabilistic stability analysis. The slope models of two typical foundations (e.
View Article and Find Full Text PDFClin Chem Lab Med
January 2025
Rare Diseases Department, General Directorate of Health Services, Turkish Ministry of Health, Ankara, Türkiye.
Simulation-based approaches for setting indirect outcome-based analytical performance specifications (APS) predominantly involve test repetition through analytical reruns or resampling. These methodologies assess the agreement between original and simulated measurement results, determining the APS corresponding to pre-established performance thresholds. For APS related to imprecision and bias, both analytical performance characteristics (APCs) are typically considered in simulations, whereas for APS regarding measurement uncertainty, bias is excluded in alignment with traceability standards.
View Article and Find Full Text PDFJ Dent
January 2025
Department of Oral & Maxillofacial Radiology, Peking University School & Hospital of Stomatology, Beijing 100081, China; National Center for Stomatology & National Clinical Research Center for Oral Diseases, Beijing 100081, China; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China; Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. Electronic address:
Objectives: In this study, artificial intelligence techniques were used to achieve automated diagnosis and classification of temporomandibular joint (TMJ) degenerative joint disease (DJD) on cone beam computed tomography (CBCT) images.
Methods: An AI model utilizing the YOLOv10 algorithm was trained, validated and tested on 7357 annotated and corrected oblique sagittal TMJ images (3010 images of normal condyles and 4347 images of condyles with DJD) from 1018 patients who visited Peking University School and Hospital of Stomatology for temporomandibular disorders and underwent TMJ CBCT examinations. This model could identify DJD as well as the radiographic signs of DJD, namely, erosion, osteophytes, sclerosis and subchondral cysts.
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