AI Article Synopsis

  • The study examines how hemodialysis affects the diagnosis of depression in end-stage renal disease (ESRD) patients, given the overlap between depression symptoms and uremic symptoms.
  • Conducted from November 2018 to April 2019, the research included 163 participants who completed the Patient Health Questionnaire (PHQ-9) to assess their depression symptoms before and after undergoing hemodialysis.
  • Results showed a high prevalence of depressive symptoms both before (48.5%) and after (46.6%) hemodialysis, with no significant difference in depression scores, highlighting the need for regular depression screening in these patients.

Article Abstract

Objectives: An overlap between the somatic symptoms of depression and those of uremia seen in end-stage renal disease (ESRD) patients may affect the diagnosis of depression. This study aims to evaluate the effect of hemodialysis on the diagnosis of depression among patients on maintenance hemodialysis as dialysis diminishes the uremic symptoms, and to compare depression scores before and after dialysis.

Methods: This was a cross-sectional analytic study conducted from November 2018 through April 2019, in three tertiary hospitals. Consenting participants aged 18 years or older, who had received hemodialysis for at least three months were included. The Patient Health Questionnaire (PHQ-9) tool was used to collect patients' data and to identify symptoms of depression Pre- and post-hemodialysis. Depression scores were compared using the paired sample Wilcoxon rank test or the McNemar test, where appropriate.

Results: Overall, 163 participants were enrolled in the study. The average age of the participants was 56.5 years old, whereas 44.8% were females. The prevalence of depressive symptoms before hemodialysis was 48.5%, with prevalence of mild, moderate and moderately severe of 34.4%, 11.7% and 2.5%, respectively. On the other hand, the prevalence of depressive symptoms after hemodialysis was 46.6% with 36.8%, 9.2% and 0.6% of the participants reporting mild, moderate and moderately severe symptoms, respectively. We found no significant difference in depression scores before and after dialysis (p-values > 0.05).

Conclusion: Our study supports the fact that the prevalence of depression is high among patients with ESRD on maintenance hemodialysis. We didn't find a significant difference in depression scores among hemodialysis patients before and after dialysis, with negligible effect of uremic symptoms on the diagnosis of depression. We suggest adopting routine screening of depression among this high-risk group of patients.

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http://dx.doi.org/10.1177/0091217420973489DOI Listing

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