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Complete genome sequence of Micromonospora craniellae LHW63014, a potential metal ion-chelating agent producer. | LitMetric

Complete genome sequence of Micromonospora craniellae LHW63014, a potential metal ion-chelating agent producer.

Mar Genomics

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address:

Published: June 2021

Micromonospora craniellae LHW63014 is a novel marine Micromonospora, isolated from a Craniella species sponge collected in the South China Sea. In this study, we report the complete genome sequence of M. craniellae LHW63014, which is comprised of a circular chromosome of 6,839,926 bp with the G + C content of 70.9 mol%. The complete genome contained 6572 protein-coding genes, 48 tRNA genes, and 9 rRNA genes. Genomic annotations revealed that 79.09% of the protein-coding genes were assigned to the COG database, among which, the abundant genes were predicted to be involved in transcription, replication, recombination and repair, and amino acid transport and metabolism. Secondary metabolites prediction using antiSMASH revealed that 22 biosynthetic gene clusters (BGC) of secondary metabolites were located in the genome of M. craniellae LHW63014, 19 of which showed low similarity (<50%) to known BGCs and 5 of which showed the closest homology with BGCs encoding metal ion-chelating agents, indicating the immense potential of M. craniellae LHW63014 to produce a wide variety of novel antibiotics, especially for metal ion-chelating agents.

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Source
http://dx.doi.org/10.1016/j.margen.2020.100830DOI Listing

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