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Article Synopsis
  • * Histological findings included epithelial acanthosis and melanin incontinence, with TRP2-positive melanocytes found in all cases, while T-lymphocytes predominantly outnumbered B-lymphocytes.
  • * A broader scoping review identified 85 additional cases, predominantly in females and black-skinned individuals, suggesting that oral melanoacanthoma primarily affects the buccal mucosa and may arise from specific immune cell involvement.
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Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip: An Unusual Association and Immunohistochemical Analysis.

Indian J Dermatol

January 2022

Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Article Synopsis
  • Oral melanoacanthoma is a rare lesion with increased keratinocyte growth and melanin-rich dendritic melanocytes, while plasma cell cheilitis (PCC) is an inflammatory condition characterized by a dense infiltration of plasma cells, mainly affecting the lower lip.
  • The study presents a unique case of a 59-year-old male with an unusual combination of melanoacanthoma, PCC, and Langerhans cell hyperplasia (LCHyp) occurring on the lower lip, showcasing the varied nature of these lesions.
  • Histological analysis utilized stains like Fontana-Masson and HMB-45 to identify dendritic melanocytes, along with markers like MUM1/IRF4 to show plasma
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[Pigmented lesions of the mucosa].

Dermatologie (Heidelb)

September 2022

Hautklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, Erlangen, Deutschland.

Article Synopsis
  • - Pigmented lesions in the mouth are common and can be confusing for both patients and doctors due to their varied causes and potential risks, including malignancy.
  • - These lesions can be categorized as either focal (like melanotic macules or nevi) or multifocal/diffuse (often linked to drugs or medical conditions), with some being benign and others necessitating further investigation.
  • - Understanding the characteristics and causes of these lesions is crucial for accurately assessing their nature and determining whether additional testing is required for diagnosis.
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The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections.

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