The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an 'all-optical' combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754708 | PMC |
| http://dx.doi.org/10.1016/j.cell.2020.09.061 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Scientific Histories of Hippocampal Research: Introduction to the Special Issue.
Hippocampus
January 2025
Cognitive Science Program and Department of Psychology, University of Arizona, Tucson, Arizona, USA.
Numerous scientific advances and discoveries have arisen from research on the hippocampal formation. This special issue provides first-person historical descriptions of these advances and discoveries in hippocampal research, written by those directly involved in the research. This is the first section of a special issue that will also include future articles on this topic.
View Article and Find Full Text PDFThe HIP mouse and all of its organs are completely invisible to allogeneic immune cells.
iScience
January 2025
Sana Biotechnology Inc., 1 Tower Place, South San Francisco, CA, USA.
Hypoimmune (HIP) allogeneic cell therapeutics hold the promise to allow off-the-shelf treatments for a broad patient population. Our HIP approach includes the depletion of major histocompatibility complex (MHC) class I and II molecules and the overexpression of Cd47. Here, we report the engineering of HIP mice that stably exhibit the HIP phenotype in all cell types.
View Article and Find Full Text PDFAutologous Neurosensory Retinal Flap Transplantation in a Porcine Model of Retinal Hole.
Ophthalmol Sci
November 2024
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Purpose: Autologous retinal transplantation has been successfully employed in the treatment of large and myopic macular holes that are refractory to standard surgical treatments. Patients transplanted with a peripheral neurosensory retinal graft have shown unexpected improvements in visual acuity. The study aims to investigate if neural integration of the graft takes place in a porcine model of retinal hole.
View Article and Find Full Text PDFThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells.
Cell Chem Biol
December 2024
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable" proteins, and several PROTACs have reached the stage of clinical candidates. However, the roles of cellular transmembrane transporters in PROTAC uptake and efflux remain underexplored.
View Article and Find Full Text PDFFloral morphological and chemical analyses of Dienia flowers (Orchidaceae, Malaxidinae) relative to pollination processes.
Sci Rep
January 2025
School of Earth and Environmental Sciences, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Dienia is a small, pantropical genus of epidendroid Malaxideae orchids. The floral lip is upwardly directed and does not serve as a landing platform for pollinators. This role has been assumed by sepals and/or gynostemium or whole inflorescence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!