Brain simplifying principles can improve robot capabilities, but currently robotic control takes different paths.
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The promise of AI in healthcare: transforming communication and decision-making for patients.
J Commun Healthc
January 2025
Venditti Consulting, LLC, Westport, CT, United States.
By addressing communication gaps, the integration of AI tools in healthcare has a greater ability to improve decision-making and to empower patients with more control over their health. Current systems for navigating healthcare - such as finding providers or understanding costs - are fragmented and cumbersome, often leaving patients frustrated and uninformed. An AI Healthcare Assistant App, leveraging advances in health IT interoperability, price transparency, and user-centred design, could simplify these processes.
View Article and Find Full Text PDFEfficacy of urethral suspension-assisted urethral anastomosis as a treatment for complex long-segment posterior urethral stricture.
World J Urol
January 2025
Department of Urology, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Eastern Institute of Urologic Reconstruction, Shanghai, 200233, China.
Purpose: To determine the clinical effects of urethral suspension-assisted urethral anastomosis on complex long-segment posterior urethral stricture and describe the technical aspects of this procedure.
Materials And Methods: The clinical data for 24 patients who underwent urethral suspension-assisted urethral anastomosis for complex long-segment posterior urethral stricture between March 2021 and March 2024 were retrospectively analyzed. The surgical procedure comprises the following four steps: creation of an inverted Y-shaped incision in the perineum; mobilization of the urethra up to the penile-scrotal junction followed by dissection and separation of the septum of the corpus cavernosum; separation of the inferior pubic symphysis, excising a portion of the inferior pubic symphysis bone tissue and thoroughly clearing the scar tissue surrounding the proximal urethra; and suturing and suspension of the proximal urethra and surrounding tissues at the 2, 5, 7, and 10 o'clock positions, ensuring complete exposure of the proximal urethral mucosa and tension-free anastomosis between the proximal and distal urethra.
Challenges and insights of transferring animal maze studies principles to human spatial learning research.
Sci Rep
January 2025
Research Institute for Brain Development and Peak Performance, RUDN University, Moscow, Russia.
Maze tasks, originally developed in animal research, have become a popular method for studying human cognition, particularly with the advent of virtual reality. However, these experiments frequently rely on simplified environments and tasks, which may not accurately reflect the complexity of real-world situations. Our pilot study aims to transfer a multi-alternative maze with a complex task structure, previously demonstrated to be useful in studying animal cognition, to studying human spatial cognition.
View Article and Find Full Text PDFThe international symposium ASOBIOTICS 2024 brought together scientists across disciplines to discuss the challenges of advancing antibacterial antisense oligomers (ASOs) from basic research to clinical application. Hosted by the Helmholtz Institute for RNA-based Infection Research (HIRI) in Wurzburg, Germany, on September 12-13th, 2024, the event featured presentations covering major milestones and current challenges of this antimicrobial technology and its applications against pathogens, commensals, and bacterial viruses. General design principles and modification of ASOs based on peptide nucleic acid (PNA) or phosphorodiamidate-morpholino-oligomer (PMO) chemistry, promising cellular RNA targets, new delivery technologies, as well as putative resistance mechanisms were discussed.
View Article and Find Full Text PDFModular cloning of multigene vectors for the baculovirus system and yeast.
J Mol Biol
January 2025
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University Clayton Victoria Australia; EMBL-Australia Clayton Victoria Australia. Electronic address:
Recombinant macromolecular complexes are often produced by the baculovirus system, using multigene expression vectors. Yet, the construction of baculovirus-compatible multigene expression vectors is complicated and time-consuming. Furthermore, while the baculovirus and yeast are popular protein expression systems, no single method for multigene vector construction is compatible with both.
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