AI Article Synopsis
- Female genital schistosomiasis (FGS) impacts around 56 million women in sub-Saharan Africa and is linked to increased HIV infection risk.
- A review of studies published until December 2018 found a strong connection between schistosomiasis and HIV, with analyses revealing an odds ratio of 2.3 for HIV among those with schistosomiasis.
- The study suggests that improving FGS understanding could help in HIV prevention, and the WHO's mass drug administration policy might reduce HIV rates among affected populations.
Article Abstract
Background: Female genital schistosomiasis (FGS) affects up to 56 million women in sub-Saharan Africa and may increase risk of HIV infection.
Methods: To assess the association of schistosomiasis with HIV infection, peer-reviewed literature published until 31 December 2018 was examined and a pooled estimate for the odds ratio was generated using Bayesian random effects models.
Results: Of the 364 abstracts that were identified, 26 were included in the summary. Eight reported odds ratios of the association between schistosomiasis and HIV; one reported a transmission hazard ratio of 1.8 (95% CI, 1.2-2.6) among women and 1.4 (95% CI, 1.0-1.9) among men; 11 described the prevalence of schistosomiasis among HIV-positive people (range, 1.5-36.6%); and six reported the prevalence of HIV among people with schistosomiasis (range, 5.8-57.3%). Six studies were selected for quantitative analysis. The pooled estimate for the odds ratio of HIV among people with schistosomiasis was 2.3 (95% CI, 1.2-4.3).
Conclusions: A significant association of schistosomiasis with HIV was found. However, a specific summary estimate for FGS could not be generated. A research agenda was provided to determine the effect of FGS on HIV infection. The WHO's policy on mass drug administration for schistosomiasis may prevent HIV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883428 | PMC |
| http://dx.doi.org/10.1016/j.ijid.2020.10.088 | DOI Listing |
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