AI Article Synopsis
- SETD3 is a unique protein in the SET-domain family, recognized as the first known histidine methyltransferase in animals, specifically targeting histidine 73 (His73) on actin.
- This review highlights recent findings about SETD3, including its structure, how it recognizes substrates, and its roles in physiological processes.
- The paper discusses the potential links between SETD3 and human cancers, raising questions to encourage further exploration of this newly identified enzyme's significance.
Article Abstract
SETD3 belongs to a family of SET-domain containing proteins. Recently, SETD3 was found as the first and so-far the only known metazoan histidine methyltransferase that catalyzes actin histidine 73 (His73) methylation, a pervasive modification which was discovered more than 50 years ago. In this review, we summarize some recent advances in SETD3 research, focusing on structural properties, substrate-recognition features, and physiological functions. We particularly highlight potential pathological relevance of SETD3 in human cancers and raise some questions to promote discussion about this novel histidine methyltransferase.
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| http://dx.doi.org/10.1016/j.bbcan.2020.188465 | DOI Listing |
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