Purpose: The aim of this study was to determine the prevalence of canine transmigration in the maxilla and mandible and to perform a 3-dimensional examination of impacted canines (ICs) on cone-beam computed tomography (CBCT) images.
Materials And Methods: CBCT images of 35 transmigrated and 35 nontransmigrated canines (control group) were analyzed. Associations between gender, jaw, dental anomalies associated with ICs, adjacent lateral status, the status of deciduous canine, contact of the apical region with the cortex, contact of the crown with the cortex, canine location, resorption of adjacent teeth and severity, periodontal contour of adjacent teeth, odontoma, root status of the canine, cyst formation, and age groups of patients with transmigration were evaluated.
Results: The prevalence of unilateral canine transmigration was 1.14%. Unilateral canine transmigration was less common in the mandible (0.52%) than in the maxilla (0.62%). ICs were significantly more frequently located on the lingual side. Resorption, the absence of contact between permanent and deciduous canines, and older age were significantly associated with transmigration. Resorption of adjacent teeth did not show significant differences according to transmigration status and gender, whereas nontransmigrated canines were significantly more commonly associated with periodontal destruction.
Conclusions: The status of associated deciduous canines, location on the lingual side, and older age may be associated with transmigration of ICs. Conversely, transmigration is not significantly associated with the destruction of adjacent structures. CBCT is a valuable tool for comprehensive evaluations of impacted and transmigrated teeth.
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http://dx.doi.org/10.1016/j.joms.2020.10.002 | DOI Listing |
Cureus
December 2024
Neurosurgery, Penn State College of Medicine, Hershey, USA.
Loeffler's syndrome is a rare, benign respiratory disease usually associated with peripheral eosinophilia, first described by Wilhelm Loeffler in 1932. It is caused by the larvae of helminths such as hookworms, , and S that transmigrate through the lungs during the active phase of infection. We present a case of a 53-year-old man who complained of a productive cough with intermittent hemoptysis and left-sided posterior chest pain.
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January 2025
Laboratory of Pathology of Implant Infections, Laboratory of Immunorheumatology and Tissue Regeneration, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
SUMMARY is a major human pathogen. It can cause many types of infections, in particular bacteremia, which frequently leads to infective endocarditis, osteomyelitis, sepsis, and other debilitating diseases. The development of secondary infections is based on the bacterium's ability to associate with endothelial cells lining blood vessels.
View Article and Find Full Text PDFAging Cell
January 2025
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Streptococcus pneumoniae (Sp; pneumococcus), the most common agent of community-acquired pneumonia, can spread systemically, particularly in the elderly, highlighting the need for adjunctive therapies. The airway epithelial barrier defends against bacteremia and is dependent upon apical junctional complex (AJC) proteins such as E-cadherin. After mouse lung challenge, pneumolysin (PLY), a key Sp virulence factor, stimulates epithelial secretion of an inflammatory eicosanoid, triggering the infiltration of polymorphonuclear leukocytes (PMNs) that secrete high levels of neutrophil elastase (NE), thus promoting epithelial damage and systemic infection.
View Article and Find Full Text PDFImmunol Cell Biol
January 2025
Trinity Translational Medicine Institute & Department of Clinical Medicine, Trinity College Dublin, St James's Hospital, Dublin, Republic of Ireland.
The αβ integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1, but the pathways that regulate LFA-1-mediated T-cell polarity and migration are not fully understood. In this study we screened two RNAi libraries targeting G protein-coupled receptors (GPCR)/GPCR-associated proteins and kinases in a HuT 78 T cell line model of LFA-1-stimulated T-cell migration. Based on staining of the actin cytoskeleton, multiple parameters to measure cell morphology were used to assess the contribution of 1109 genes to LFA-1-mediated T-cell polarity and migration.
View Article and Find Full Text PDFAm J Gastroenterol
November 2024
Adiso Therapeutics, Inc., Concord, Massachusetts, USA.
Introduction: A need for better treatment options for moderate to severe ulcerative colitis (UC) persists because of the efficacy and safety limitations of current therapies. Neutrophil epithelial transmigration is associated with the characteristic colonic mucosal inflammation in and very likely involved with the pathogenesis and clinical symptoms of UC. ADS051 is a small-molecule inhibiting neutrophil migration and activation, which are potentially important therapeutic targets in UC.
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