For the last 25 years, Online Mendelian Inheritance in Animals (OMIA) has been providing free global access to an ever-increasing record of discoveries made by animal geneticists around the world. To mark this 25-year milestone, this document provides a brief account (including some pre-history) of how OMIA came to be; some timelines of important discoveries and advances in the genetics of the animal species covered by OMIA, gleaned from the OMIA database; and an analysis of the current state of knowledge regarding likely causal variants of single-locus traits in OMIA species, also gleaned from the OMIA database.
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Exploration of the mechanism of tetramethoxyflavone in treating osteoarthritis based on network pharmacology and molecular docking.
Tzu Chi Med J
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Pharmacy College, Gannan Medical University, Ganzhou, Jiangxi, China.
Objectives: This study aimed to explore the potential mechanisms of TMF (5,7,3',4'-tetramethoxyflavone) in treating osteoarthritis (OA) using network pharmacology and molecular docking.
Materials And Methods: Databases including SwissTargetPrediction, BATMAN-TCM, PharmMapper, TargetNet, SuperPred, and SEA were utilized to screen the targets of TMF. "OA" was used as the disease keyword to predict OA-related genes through GeneCards, Therapeutic Target Database, PharmGKB, Online Mendelian Inheritance in Man, and Comparative Toxicogenomics Database.
Alcohol consumption and allergic diseases: Mendelian randomization evidence from China.
Glob Health Action
December 2024
College of Economics and Management, China Agricultural University, Beijing, China.
Background: The prevalence of allergic diseases in China has risen significantly over the past decades, affecting the quality of life for approximately 40% of the population.
Objectives: This study aimed to integrate survey and genomic data to explore the potential causal relationship between alcohol consumption and allergic diseases.
Method: In collaboration with a leading genetic testing company in China, we collected data on 3,041 participants via an online survey between December 2018 and October 2019.
Fertility problems in men carrying chromosome 7 inversion: A retrospective, observational study.
Medicine (Baltimore)
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Department of Urology, The First Hospital of Tsinghua University, Beijing, China.
Infertility is a worldwide public health issue. Fifty percent of infertile couples are male-only. A number of male infertility etiologies are significantly influenced by chromosomal abnormalities.
View Article and Find Full Text PDFSerum metabolites and risk of aortic dissection: a two-sample Mendelian randomization study.
Indian J Thorac Cardiovasc Surg
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Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001 Anhui China.
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View Article and Find Full Text PDFIntegrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease.
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Department of Pharmacy, Jiangbei Campus of The First Affiliated Hospital of Army Medical University (No. 958 Hospital of PLA Army), Chongqing, 400020, China.
To explore the pharmacological mechanism of Changpu-Yizhi-Wan (CYW) in the treatment of Alzheimer's disease (AD) from the perspective of ferroptosis based on network pharmacology and experimental verification. The Encyclopedia of Traditional Chinese Medicine 2.0 (ETCM2.
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