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Hyperacute silicosis after bronchoscopy-induced melanoptysis in a lung transplant patient. A first report in literature.
Interdiscip Cardiovasc Thorac Surg
January 2025
Critical Care Department, Finis Terrae University. Santiago, Chile.
Silicosis, a fibrotic lung disease caused by crystalline silica inhalation, presents unique challenges in lung transplantation. This case reports an unprecedented complication in a lung transplant recipient with chronic silicosis. A man in his 60 s, post left single-lung transplantation for silica-induced pneumoconiosis, developed acute respiratory deterioration following routine bronchoscopy.
View Article and Find Full Text PDFPulmonary and systemic effects of inhaled crystalline silica in the HOCl-induced mouse model of systemic sclerosis: An experimental model of Erasmus syndrome.
Clin Immunol
December 2024
Univ Rennes, INSERM, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:
Occupational exposure to crystalline silica is etiologically linked to an increased incidence of systemic sclerosis (SSc), also called Erasmus syndrome. The underlying mechanisms of silica-related SSc are still poorly understood. We demonstrated that early and repeated silica exposure contribute to the severity of SSc symptoms in the hypochloric acid (HOCl)-induced SSc mouse model.
View Article and Find Full Text PDFInflammatory biomarkers in workers exposed to silica dust: integrative review.
Rev Bras Med Trab
November 2024
Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Introduction: Silicosis is a severe, progressive, fibrosing lung disease caused by the inhalation of free crystalline silica dust; it is the most prevalent pneumoconiosis worldwide. It is associated with a chronic inflammatory process triggered by silica particles in the pulmonary alveoli. Alveolar macrophages play a key role in the pathogenesis of silicosis, with additional contributions from polymorphonuclear cells, epithelial cells, and the release of inflammatory mediators.
View Article and Find Full Text PDFSystemic sclerosis, silica exposure and cellular therapies: The sand in the gears?
Rev Med Interne
July 2024
Unité de médecine interne (UF04): CRMR MATHEC, maladies auto-immunes et thérapie cellulaire, centre de référence des maladies auto-immunes systémiques rares d'Île-de-France, recherche clinique en hématologie, immunologie et transplantation, URP3518, hôpital St-Louis, AP-HP, université Paris Cité, IRSL, 75010 Paris, France; Department of Medicine, McGill University, H3A 1A1 Montreal, Canada.
Systemic sclerosis (SSc) is a chronic orphan autoimmune disease with the highest mortality rate among rheumatic diseases. SSc-related interstitial-lung disease (ILD) remains among the leading causes of SSc-related mortality with still few therapeutic effective strategies. In patients with crystallin silica exposure, SSc is recognized as an occupational disease according to the French social security system (Table 25A of the general insurance regimen).
View Article and Find Full Text PDFPathologic Findings in Severe Coal Workers' Pneumoconiosis in Contemporary US Coal Miners.
Arch Pathol Lab Med
July 2024
the Department of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois Chicago, Chicago (Almberg, Iwaniuk, Go, Cohen).
Context.—: The pathology of coal workers' pneumoconiosis (CWP) and its most severe form-progressive massive fibrosis (PMF)-in US coal miners has changed in recent years. Severe disease is occurring in younger miners and has been linked to an increase in silica dust exposure.
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