Synthesis and antiproliferative activities of lupanol derivatives towards human esophageal squamous carcinoma cells.

A series of lupanol derivatives were synthesized and evaluated for their inhibitory activities against three human esophageal squamous carcinoma cells lines, Eca-109, TE-1 and EC-9706. Among lupanol derivatives, seven were new compounds, and lupanol cinnamate analogues and , hydrazone analogues and presented high activities towards all the tested tumour cells, even higher activities than those of doxorubicine.