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[Real-time rectal swab Xpert Carba-R assay for early warning of CRO bloodstream infection in patients undergoing hematopoietic stem cell transplant: a clinical feasibility study].
Zhonghua Xue Ye Xue Za Zhi
November 2024
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
This study aimed to analyze the homology between carbapenem-resistant organisms (CRO) intestinal colonization strains and bloodstream infection (BSI) strains in patients undergoing hematopoietic stem cell transplantation (HSCT), confirming the clinical use of the real-time rectal swab Xpert Carba-R assay, and investigate its feasibility in early warning of BSI. Drug-resistant strains obtained from rectal swabs and blood culture samples of patients undergoing the same HSCT from January 2021 to December 2021 were collected and analyzed. The homology of the CRO intestinal colonization and BSI strains was confirmed using strain identification, antimicrobial resistance phenotyping, whole genome sequencing (WGS), multilocus sequence typing (MLST), and carbapenemase type identification.
View Article and Find Full Text PDFEarly detection of OXA-48 producing Klebsiella pneumoniae with the use of rapid antibiotic susceptibility testing.
Eur J Clin Microbiol Infect Dis
December 2024
Department of Medical Microbiology, Ghent University Hospital, Ghent, Belgium.
Rapid antimicrobial susceptibility testing of positive blood cultures can enhance antimicrobial stewardship and patient outcomes. We present a case where OXA-48-producing Klebsiella pneumoniae with low-level carbapenem resistance was suspected 6 h after blood-culture positivity, based on ASTar system (Q-Linea, Sweden) results. OXA-48 carbapenemase presence was confirmed by the OXA-48 K-SeT lateral flow assay (Coris, Belgium) on a short-term subculture.
View Article and Find Full Text PDFAccuracy of Xpert Carba-R Assay for the Diagnosis of Carbapenemase-producing Organisms from Rectal Swabs in Asia: a Diagnostic Meta-analysis.
Indian J Microbiol
September 2024
Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan, People's Republic of China.
The Cepheid Xpert Carba-R assay has been demonstrated to be reliable for rapid detection of carbapenemase-producing orgnisms (CPO) directly from rectal swabs but the performance of which remains unclear in Asia.We searched PubMed, EMBASE and Cochrane Library databases to identify studies according to predetermined criteria. STATA 13.
View Article and Find Full Text PDFMethodological Evaluation of Carbapenemase Detection by Different Methods.
Pol J Microbiol
September 2024
The First Affiliated Hospital of Anhui Medical University, Hefei, China.
The global proliferation of carbapenemase-producing bacteria (CPB) has garnered significant attention worldwide. Early diagnosis of CPB and accurate identification of carbapenemases are crucial for preventing the spread of CPB and ensuring targeted antibiotic therapy. Therefore, efficient and accurate identification of carbapenemases is paramount in clinically treating diseases associated with CPB.
View Article and Find Full Text PDFBackground: The spread of Carbapenemase-producing Organisms (CPO) remains a major threat globally. Within clinical settings, the existing method of determining gene load involves traditional culture to determine bacterial load and polymerase-chain-reaction-based Xpert Carba-R Assay to determine carbapenemase gene type. However, there is a need for a fast and accurate method of quantifying CPO colonisation to study the risk of persistent CPO carriage.
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