AI Article Synopsis
- A surveillance program was conducted on colorectal cancer patients post-surgery to identify asymptomatic recurrence over a 3-year period using different follow-up strategies.
- The study randomly assigned patients to either a conventional follow-up group (arm A) or a group receiving 18-FDG PET/CT (arm B) to compare effectiveness in detecting cancer recurrence.
- Results showed that while more patients in arm B experienced recurrence, PET/CT did not significantly enhance the detection or surgical treatment rates compared to traditional methods.
Article Abstract
Background: A surveillance program was performed in colorectal cancer (CRC) patients after surgery, to diagnose asymptomatic recurrence.
Aims: To assess whether 18-FDG positron emission tomography/CT (PET/CT) improved the detection of recurrence during a 3-year follow-up.
Methods: A multicentre, two-arm randomised prospective trial comparing different 36-month follow-up strategies. Complete colonoscopy was performed at baseline and after 3 years and clinical exams with imaging every 3 months. The conventional arm (A) received carcinoembryonic antigen, liver echography, and alternated between lung radiography and computed tomography (CT) scans. The experimental arm (B) received PET/CT.
Results: A total of 365 patients with colon (79.4%) or rectal cancer (20.6%), stages II (48.2%) or III (50.8%), were enroled in this study. At 36 months, intention-to-treat analysis revealed recurrence in 31 (17.2%) patients in arm A and 47 (25.4%) in arm B (p = 0.063). At 3 years, 7 of 31 relapses (22.5%) in arm A were surgically treated with curative intent, compared to 17 of 47 (36.2%) in arm B (p = 0.25). The rates of recurrence and new cancers were higher in arm B than arm A (p = 0.038).
Conclusions: PET/CT follow-up every 6 months did not increase the rate of recurrence at 3 years or the rate of surgically treated recurrence compared with conventional follow-up.
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| http://dx.doi.org/10.1016/j.dld.2020.10.012 | DOI Listing |
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