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| http://dx.doi.org/10.1016/j.mayocp.2020.09.025 | DOI Listing |
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The great automatic grammatizator: On the use and misuse of large language models in scientific and academic writing.
JAAD Int
February 2025
Department of Dermatology, Center for Global Health, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Florida Center for Dermatology, St Augustine, Florida.
Practical Considerations for the Use of the Rapid AcuStar ADAMTS13 Activity Assay in the Diagnosis of Acute Thrombotic Thrombocytopenic Purpura (TTP).
J Clin Med
July 2024
The Roald Dahl Centre for Haemostasis and Thrombosis, Liverpool University Hospital NHS Trust, Liverpool L7 8XP, UK.
Article Synopsis
- Conventional management of acute TTP involves the immediate treatment of suspected cases while waiting for ADAMTS13 deficiency test results, with new rapid assays like the HemosIL AcuStar improving accessibility and diagnostic speed.
- A multi-centre study examined discrepancies between rapid (AcuStar) and traditional ELISA assays in patients suspected of TTP, highlighting that strong clinical suspicion correlates well with results while low suspicion may lead to inconsistencies.
- For patients with high suspicion of acute TTP, the AcuStar assay matched the ELISA results accurately, whereas discrepancies (particularly in cancer or sepsis cases) occurred when TTP suspicion was low, stressing the need for solid testing protocols in diagnosis.
Revisiting the full blood count: Circulating blood cells and their role in coagulation.
Br J Haematol
October 2024
Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
There has been an expansion in our understanding of the multifaceted roles of circulating blood cells in regulating haemostasis and contributing to thrombosis. Notably, there is greater recognition of the interplay between coagulation with inflammation and innate immune activation and the contribution of leucocytes. The full blood count (FBC) is a time-honoured test in medicine; however, its components are often viewed in isolation and without consideration of their haemostatic and thrombotic potential.
View Article and Find Full Text PDFRestoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.
J Heart Lung Transplant
December 2024
Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Cardiothoracic Surgery and Transplantation, Lund University Hospital, Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden; Lund Stem Cell Centre, Lund University, Lund, Sweden. Electronic address:
Article Synopsis
- * Twelve pigs were used to induce aspiration lung injury, and after assessing the lungs, they were divided into two groups: one with NET removal plus EVLP and another with only EVLP.
- * Results showed that the lungs treated with NET removal had significantly improved function and morphology, indicating the removal of NETs during EVLP could lead to better outcomes in lung transplantation and increase the number of available donor lungs.
The convergent model of coagulation.
J Thromb Haemost
August 2024
Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK; The Roald Dahl Haemostasis and Thrombosis Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK. Electronic address:
It is increasingly apparent that the pathologic interplay between coagulation and innate immunity, ie, immunothrombosis, forms the common basis of many challenges across the boundaries of specialized medicine and cannot be fully explained by the conventional concepts of cascade and cell-based coagulation. To improve our understanding of coagulation, we propose a model of coagulation that converges with inflammation and innate immune activation as a unified response toward vascular injury. Evolutionarily integral to the convergent response are damage-associated molecular patterns, which are released as a consequence of injury.
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