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In cases of large mandibular continuity defects resulting from malignancy resection, the current standard of care involves using patient-specific/custom titanium reconstruction plates along with autogenous grafts (fibula, scapula, or iliac crest segments). However, when grafts are not feasible or desired, only the reconstruction plate is used to bridge the gap. Unfortunately, metal osteosynthesis and reconstruction plates, including titanium, exhibit adverse effects such as stress-shielding and limitations in accurate postoperative irradiation (especially with proton-beam therapy).

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Nothronychus graffami was a large therizinosaur represented by a single well-preserved individual from the Turonian Tropic Shale of southern Utah. It is characterized by an enlarged abdomen, small tail, and an extensively pneumatized axial skeleton, and is frequently regarded as herbivorous. Given the overall tail reduction and the development of a wide fused synsacrum with widely spaced acetabulae, it is reconstructed with an anteriorly rotated femur and a displaced resting ground reaction force anterior to the center of mass.

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