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Efficacy and Safety of Three Cycles of TIP and Sequential High Dose Chemotherapy in Patients with Testicular Non-Seminomatous Germ Cell Tumors.
J Clin Med
December 2024
Department of Medical Oncology, University of Health Sciences, Gulhane School of Medicine, Ankara 06018, Turkey.
: Salvage treatment options have not been validated in relapsed or refractory germ cell tumors. Moreover, the study populations including these patients have different heterogeneities. This study aimed to evaluate the efficacy and safety of three cycles of TIP sequential high-dose chemotherapy in patients with testicular non-seminomatous germ cell tumors who relapsed or had a refractory course after first-line platinum-based chemotherapy.
View Article and Find Full Text PDFSpinal Metastases in Non-Seminomatous Germ Cell Testicular Tumors: Prognosis and Integrated Therapeutic Approaches-A Systematic Review with an Institutional Case Illustration.
Curr Oncol
November 2024
Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy.
(1) Background: Testicular cancer, although accounting for only 0.5% to 1% of all solid male cancers, is the most common malignancy in males aged 15 to 35 years. Non-seminomatous germ cell tumors (NSGCT) represent nearly half of all testicular germ cell tumors and are associated with a more aggressive clinical course.
View Article and Find Full Text PDFMucinous Cystadenoma Arising in Post-Treatment Non-Seminomatous Germ Cell Tumor: A Rare Occurrence.
Cureus
November 2024
Pathology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Germ cell tumors, the most common of the testicular neoplasms, originate from primordial germ cells. These tumors are known for their totipotent nature, capable of differentiating into various cell types. This case report presents a rare occurrence of mucinous cystadenoma in a patient who received chemotherapy for metastatic left non-seminomatous germ cell tumor (NSGCT) of the testis.
View Article and Find Full Text PDFA Rare Case of an Aggressive Mixed Germ Cell Tumor Following Testicular Torsion.
Cureus
November 2024
Urology, Broward Health Coral Springs, Coral Springs, USA.
Testicular cancer is one of the leading malignancies affecting young men, with germ cell tumors (GCTs) being the most prevalent type. These tumors are classified into two main subtypes: seminomas and non-seminomatous germ cell tumors (NSGCTs), with the latter known for their higher likelihood of metastasis. Early detection through imaging and tumor markers like alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) is crucial for favorable outcomes.
View Article and Find Full Text PDFPrimary retroperitoneal lymph node dissection in clinical stage 2a/b non-seminomatous germ cell tumour.
BJU Int
December 2024
Department of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.
Objectives: To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.
Materials And Methods: Data from 17 institutions were collected, comprising 305 men who underwent primary RPLND for CS 2 NSGCT. Regression analyses were conducted to predict histology in the RPLND specimen and disease-free survival (DFS).
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