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Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. | LitMetric

AI Article Synopsis

  • Non-alcoholic fatty liver disease (NAFLD) is linked to liver lipid buildup and insulin resistance, with inositols (INS) possibly playing a beneficial role as they are involved in many bodily functions and can be sourced from diet and supplements.
  • A systematic review identified 10 animal studies and one human trial, finding that INS deficiency led to increased liver fat in animals, while supplementation reduced liver triglycerides and cholesterol while preserving liver structure.
  • The human trial showed that Pinitol supplementation significantly lowered liver fat and other harmful lipid levels, suggesting the potential of INS as a therapeutic option for NAFLD, but more extensive clinical trials are needed for conclusive results.

Article Abstract

Liver lipid accumulation is a hallmark of non-alcoholic fatty liver disease (NAFLD), broadly associated with insulin resistance. Inositols (INS) are ubiquitous polyols implied in many physiological functions. They are produced endogenously, are present in many foods and in dietary supplements. Alterations in INS metabolism seems to play a role in diseases involving insulin resistance such as diabetes and polycystic ovary syndrome. Given its role in other metabolic syndromes, the hypothesis of an INS role as a supplement in NAFLD is intriguing. We performed a systematic review of the literature to find preclinical and clinical evidence of INS supplementation efficacy in NAFLD patients. We retrieved 10 studies on animal models assessing Myoinosiol or Pinitol deficiency or supplementation and one human randomized controlled trial (RCT). Overall, INS deficiency was associated with increased fatty liver in animals. Conversely, INS supplementation in animal models of fatty liver reduced hepatic triglycerides and cholesterol accumulation and maintained a normal ultrastructural liver histopathology. In the one included RCT, Pinitol supplementation obtained similar results. Pinitol significantly reduced liver fat, post-prandial triglycerides, AST levels, lipid peroxidation increasing glutathione peroxidase activity. These results, despite being limited, indicate the need for further evaluation of INS in NAFLD in larger clinical trials.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694137PMC
http://dx.doi.org/10.3390/nu12113379DOI Listing

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