AI Article Synopsis
- The study examined the expression patterns of tissue markers SATB1 and PTEN in relation to various kidney diseases using 32 biopsy samples, including both proliferative and non-proliferative groups.
- Both markers were found in all kidney structures, showing particularly high expression in tubular epithelial cells and significant differences in expression levels when compared to healthy control samples.
- The findings suggest SATB1 and PTEN could serve as potential indicators of kidney disease progression and warrant further investigation for their role in kidney disease treatment.
Article Abstract
Background: In present study we investigated expression pattern of the special tissue markers. SATB1 and PTEN to evaluate possible influence in pathophysiology and development of various biopsy proven kidney diseases.
Methods: The 32 kidney biopsy samples were analysed using light, immunofluorescence and electron microscopy. There were 19 samples in proliferative and 13 samples in non- proliferative group of renal diseases. As control group, 9 specimens of healthy kidney tissue taken after surgery of kidney tumour were used. SATB1 and PTEN markers were used for immunofluorescence staining. Analysed tissue structures were glomeruli, proximal convoluted tubules (PCT) and distal convoluted tubules (DCT). The number of SATB1 and PTEN cells were calculated and the data compared between kidney structures, disease groups and control specimens.
Results: Both markers were positive in all investigated kidney structures, with expression generally, more prominent in tubular epithelial cells than in glomeruli, with the highest staining intensity rate as well as highest rate of both markers in DCT of proliferative diseases group (SATB1 64.5 %, PTEN 52 %). There was statistically significant difference in SATB1 expression in all tissue structures of interest in proliferative as well as non- proliferative group compared to control group (p < 0.01-p < 0.0001). PTEN expression were found significantly decreased in PCT of both disease groups in regard to control (PTEN 25.3 % and 23.8 % vs. 41.1 % (p < 0.01 and p < 0.001 respectively).
Conclusion: SATB1 and PTEN could be considered as markers influenced in kidney disease development. SATB1/PTEN expression should be further investigated as useful markers of kidney disease activity as well as potential therapeutic target.
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| http://dx.doi.org/10.1016/j.acthis.2020.151631 | DOI Listing |
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SATB1 and PTEN expression patterns in biopsy proven kidney diseases.
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- The study examined the expression patterns of tissue markers SATB1 and PTEN in relation to various kidney diseases using 32 biopsy samples, including both proliferative and non-proliferative groups.
- Both markers were found in all kidney structures, showing particularly high expression in tubular epithelial cells and significant differences in expression levels when compared to healthy control samples.
- The findings suggest SATB1 and PTEN could serve as potential indicators of kidney disease progression and warrant further investigation for their role in kidney disease treatment.
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