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Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine.
J Hepatobiliary Pancreat Sci
January 2025
Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
In Japan, 5 years have passed since the initiation of precision cancer medicine, and recent data accumulation in familial pancreatic cancer (FPC) and hereditary pancreatic cancer is outstanding. Multigene germline panel tests (MGPTs) have revealed that 7%-18% of patients with pancreatic cancer (PC) harbor pathogenic germline variants (PGVs), almost equal to the levels of breast, ovarian, endometrial, and colorectal cancers, with a higher incidence in FPC (14%-26%). The majority of PGVs seen in PC patients are clinically actionable and associated with homologous recombination (HR) pathways (6%-10%, particularly BRCA1/2 in 5%-6%), and the clinical guidelines recommend or propose genetic testing for all PC patients.
View Article and Find Full Text PDFImplementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study.
Breast
January 2025
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Tamoxifen is an estrogen-receptor (ER) antagonist, used as adjuvant treatment of ER-positive breast cancer. It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations <16 nM face a higher risk of recurrence.
View Article and Find Full Text PDFEldecalcitol Add-On to Risedronate Reduces Bone Loss from Aromatase Inhibitors in Postmenopausal Breast Cancer Patients.
J Clin Endocrinol Metab
January 2025
Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Context: Aromatase inhibitors (AIs) cause bone loss and increase fracture risk in women with hormone receptor-positive early-stage breast cancer (HR+EBC). Bone antiresorptive agents are recommended for patients at risk of fragility fractures. Eldecalcitol, combined with bisphosphonate, increases bone mineral density (BMD) in primary osteoporosis.
View Article and Find Full Text PDFInvestigating the effect of yoga-based educational interventions on the volume and composition of breast milk in premature infant's mothers admitted to neonatal intensive care unit: A randomized controlled trial.
J Educ Health Promot
November 2024
Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Background: This study examined the effects of yoga-based educational interventions on the volume and composition of breast milk in premature infants' mothers admitted to the neonatal intensive care unit (NICU).
Materials And Methods: A randomized controlled trial was conducted on 78 primiparous mothers whose premature infants were less than 34 weeks and were hospitalized in the NICU of Ayatollah Rouhani Hospital from February 2021 to November 2022. Mothers were assigned to a control group and an experimental group, that is, yoga, using the block randomization method.
Assessing Mean Glandular Dose in Mammography in Jordan According to American College of Radiology (ACR) Standards.
Cancer Manag Res
January 2025
School of Physics, Universiti Sains Malaysia, Penang, 11800 Gelugor, Malaysia.
Introduction: Breast cancer is a significant worldwide health issue, particularly in Jordan, where early detection via mammography is essential for effective disease management. Despite the little radiation risk associated with mammography, it is crucial to monitor radiation exposure to guarantee patient safety. This study intends to assess skin entrance exposure and compute the Mean Glandular Dose (MGD) in mammography units to determine adherence to established criteria and pinpoint areas for enhancement.
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