Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popular tools for this task. Here, we present version 3 of the antiSMASH database, providing a means to access and query precomputed antiSMASH-5.2-detected biosynthetic gene clusters from representative, publicly available, high-quality microbial genomes via an interactive graphical user interface. In version 3, the database contains 147 517 high quality BGC regions from 388 archaeal, 25 236 bacterial and 177 fungal genomes and is available at https://antismash-db.secondarymetabolites.org/.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779067 | PMC |
| http://dx.doi.org/10.1093/nar/gkaa978 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains of Isolated from Rhizospheric Soils.
Microorganisms
December 2024
Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala S/N, Mexico City CP 11430, Mexico.
is a genus of Gram-positive bacteria with high GC content. It remains attractive for studying and discovering new antibiotics, antifungals, and chemotherapeutics. genomes can contain more than 30 cryptic and expressed biosynthetic gene clusters (BGC) encoding secondary metabolites.
View Article and Find Full Text PDFTwo new strains of Streptomyces with metabolic potential for biological control of pear black spot disease.
BMC Microbiol
December 2024
State Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, Alar, Xinjiang Uygur Autonomous Region, 843300, China.
Background: Pear black spot is caused by Alternaria tenuissima. It is one of the diseases of concern limiting pear production worldwide. Existing cultivation methods and fungicides are not sufficient to control early blight.
View Article and Find Full Text PDFWhole-genome sequencing and genomic analysis of four strains newly isolated from human feces.
Front Microbiol
December 2024
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Background: Numerous studies have demonstrated that is closely associated with human health. These bacteria colonize the mucus layer of the gastrointestinal tract and utilize mucin as their sole source of carbon and nitrogen. spp.
View Article and Find Full Text PDFWhole genome sequence and LC-Mass for identifying antimicrobial metabolites of Bacillus licheniformis endophyte.
AMB Express
December 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Antimicrobial resistance (AMR) represents a critical public health issue that requiring immediate action. Wild halophytic plants can be the solution for the AMR crisis because they harbor unique endophytes capable of producing potent antimicrobial metabolites. This study aimed at identifying promising and antimicrobial metabolites produced by endophytic/epiphytic bacteria recovered from the wild Bassia scoparia plant.
View Article and Find Full Text PDFWhole genome sequence data of strain E22, from Kazakhstan.
Data Brief
December 2024
Research and Production Center for Microbiology and Virology, Bogenbay batyr. Str., 105, Almaty 050010, Kazakhstan.
Article Synopsis
- - The text discusses the bacterium responsible for bacterial blight in rosaceae plants, which impacts both ornamental species and economically important fruit trees like apples and pears.
- - The research involved sequencing the E22 strain isolated in Kazakhstan using the Illumina MiSeq platform and analyzing the data with various bioinformatics tools, resulting in an assembled genome size of 3,799,623 base pairs.
- - A total of 3,462 genes were annotated from this genome, including over 3,200 protein-coding genes, offering insights into the bacterium's evolution and potential applications for developing control methods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!