The persistence of , especially in hospital environments where disinfectants are used intensively, is one of the important factors that allow this opportunistic pathogen to establish nosocomial infections. In the present study, we illustrated that . possesses adaptive resistance to the disinfectant benzalkonium chloride (BAC). This BAC adaptation was abolished in the Δ mutant, in which a gene encoding an efflux transporter belonging to the major facilitator superfamily (MFS) was deleted. The Δ mutant also showed increased susceptibility to BAC and chlorhexidine gluconate compared with a parental wild type. The expression of increased upon exposure to quaternary ammonium compounds, including BAC. Thus, the results of this study suggest that plays a role in both adaptive and nonadaptive protection of . from the toxicity of the disinfectant BAC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1139/cjm-2020-0341 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Background: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye.
Purpose: This study explored the potential therapeutic role and underlying mechanisms of NE in benzalkonium chloride (BAC)-induced dry eye disease.
Assessing the distribution and human health risks of cationic surface-active agents in honey from China.
J Hazard Mater
December 2024
State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China. Electronic address:
Cationic surface-active agents (CSAAs) can persist in ambient water, be ingested by bees, and contaminate honey. Residues of CSAAs in honey remains unknown. This study measured the residual levels of five CSAAs in 271 honey samples from China using ultrahigh-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry.
View Article and Find Full Text PDFFactors affecting mass inflow of quaternary ammonium compounds into Japanese sewage treatment plants.
J Environ Manage
December 2024
Botanical Garden, Institute of Nature and Environmental Technology, Kanazawa University, Kakumamachi, Kanazawa, Ishikawa, 920-1192, Japan.
Quaternary ammonium compounds (QACs), ecotoxic organic chemicals linked to multidrug resistance, are being used increasingly, for example to prevent the transmission of infections such as covid-19, in households, hospitals, and industry. To understand the locations, fluctuations, and fractions of QACs entering sewers, we monitored 14 QACs (benzalkonium chloride [BAC]-C8, C10, C12, C14, C16, and C18; dialkyldimethylammonium chloride [DDAC]-C8, C10, and C12; alkyltrimethylammonium chloride [ATAC]-C12, C16, and C18; benzethonium chloride; and cetylpyridinium chloride), and a disinfectant (chlorhexidine) in influent at four Japanese sewage treatment plants (STPs) five times throughout a year. Mass inflows were relatively stable throughout the year, indicating that the recent seasonal covid-19 epidemic did not greatly influence them.
View Article and Find Full Text PDFComparison of different disinfection protocols against contamination of ceramic surfaces with biofilm.
Arh Hig Rada Toksikol
December 2024
1University of Rijeka Faculty of Medicine, Department of Microbiology and Parasitology, Rijeka, Croatia.
Environmental contamination with biofilm can be a source of healthcare-associated infections. Disinfection with various biocidal active substances is usually the method of choice to remove contamination with biofilm. In this study we tested 13 different disinfection protocols using gaseous ozone, citric acid, and three working concentrations of benzalkonium chloride-based professional disinfecting products on 24-hour-old biofilms formed by two strains on ceramic tiles.
View Article and Find Full Text PDFAllergens in ophthalmic medicaments in New Zealand.
Australas J Dermatol
December 2024
Department of Dermatology, Auckland City Hospital, Te Whatu Ora Health, New Zealand.
Background/objectives: Eyelid allergic contact dermatitis (ACD) attributed to ophthalmic medications is often underreported, which can result in poor outcomes. Patch testing for eyelid ACD requires up-to-date knowledge of potential allergens. The aim of this study was to investigate allergens in ophthalmic medicaments in New Zealand.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!