Microwave assisted synthesis, characterization and biological activities of ferrocenyl chalcones and their QSAR analysis: Part II.

A series of ferrocenyl chalcones using acetylferrocene, with ferrocenyl group at the keto carbonyl group, and different aldehydes were synthesized and their bioefficacy evaluation was done against , and In continuation of our quest for potent crop protection products, in the present study, a series of 18 substituted ferrocenyl chalcones were synthesized in which ferrocenyl group was attached to the aldehyde moiety, using ferrocenecarboxyaldehyde and different acetophenones by microwave method (MM) and conventional method (CM) [: MM 1 to 5 min; CM 12-40 h] and characterized by various techniques viz. IR, LC-HRMS, H-NMR and C-NMR. fungicidal activity showed that compound, (2)-1-(5-Chloro-2-hydroxyphenyl)-3-ferrocenyl-prop-2-en-1-one ( (ED = 21.50 mg L) was found to be most active against and compound, (2)-1-(4-Bromophenyl)-3-ferrocenyl-prop-2-en-1-one ( (ED = 31.14 mg L) showed highest activity against As regards nematicidal activity, compound (2)-1-(3-Bromophenyl)-3-ferrocenyl-prop-2-en-1-one ( was more potent with LC values of 11.95, 8.07 and 4.34 mg L at 24, 48 and 72 h, respectively. QSAR study revealed that MLR for ( = 0.9834, = 0.8975) and ( = 0.9807, = 0.8713) and PLS for ( = 0.9023, = 0.7818) were the best models.