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Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.
Nat Commun
October 2024
Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2). Glucocorticoids (GC), widely used anti-inflammatory therapeutics, reportedly impart a similar phenotype (M2), but how such disparate pathways may functionally converge is unknown. We show using integrative functional genomics that M2 and M2 transcriptomes share a striking overlap mirrored by a shift in chromatin landscape in both common and signal-specific gene subsets.
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