First Report of an Strain Carrying the Colistin Resistance Determinant from a Dog in South Korea.

We studied the presence of the mobile colistin resistance gene - in isolates recovered from fecal and urine samples of companion animals, that were collected from South Korea in 2018 and 2019. The - gene was detected in one colistin-resistant . isolated from a diarrheic dog. The isolate exhibited additional resistance to multiple antimicrobials, including fluoroquinolones and third-generation cephalosporins. The - carrying isolate belonged to ST160. The pulsed-field gel electrophoresis pattern of our strain differed from those ST160 . strains previously identified from chickens in Korea. The gene was identified in the IncI2 plasmid. It was also transferred to J53 recipient strain, with a conjugation efficiency of 2.8 × 10. Average nucleotide identity analysis demonstrated that the --carrying plasmid in this study was closely related to those from patients in Korea. To the best of our knowledge, this is the first report of -1 carrying from a companion animal in South Korea. Our findings support One Health approach is necessary to prevent the dissemination of this high-risk gene.