We could study Cone Beam documents of patients consulting in ORL with standard Angle Class I occlusion (45 ND), patients consulting in orthodontics with an orthodontic Class II (51 APNS) and patients with a surgical Class II (83 APS). The used 3D biometry calculates systematically a 164 set of parameters able to take into account all kinds of disharmonies; among which 38 parameters are specifically devoted to anterior-posterior "off asymmetry" pathologies. Then the specific Artificial Intelligence (AI) programs treat morphological data and give textual diagnoses. Analysis of the global sample aims to control the efficiency, separating different sub-samples one each other: t test appreciates efficiency of each parameter to recognize clinical sub-sample. The correlation coefficient, r, between each parameter and pseudo Angle molars Class II (GMMy-Gmmy) give the importance of its tie with Class II pathology. Presentation of parameters medium values in each sub-group gives the medium profiles. By direct comparison of patient's parameters values with medium profile, it is possible to locate patient's pathology. So we can take in account new parameters like arches upper/lower gap, anterior bases upper/lower gap, compensatingparameters... It is then possible to make more secure the clinical decision.
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http://dx.doi.org/10.1684/orthodfr.2020.13 | DOI Listing |
EClinicalMedicine
October 2024
Department of Oncology, Queen's University, Kingston, Canada.
Patients with cancer expect prolonged life (overall survival, OS) or better life (quality of life, QOL) from cancer treatments. However, majority of new cancer drugs are now being approved not based on improved OS or QOL, but based on surrogate endpoints such as tumor shrinkage or delayed tumor progression. These surrogate endpoints, including their validity as a proxy for overall survival, differ based on disease settings and lines of treatment but in general, most surrogate measures have weak correlation with outcomes that matter to patients.
View Article and Find Full Text PDFEClinicalMedicine
October 2024
Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
Background: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term effects of PT have never been compared with gold-standard treatments for MDD such as pharmacotherapy or psychotherapy alone or in combination.
Methods: This is a 6-month follow-up study of a phase 2, double-blind, randomised, controlled trial involving patients with moderate-to-severe MDD.
Front Med (Lausanne)
December 2024
Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
Objectives: This pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).
Methods: Clinical and ultrasound assessments were conducted at baseline (t0) and subsequently at 1 (t1), 3 (t3), and 6 (t6) months. Ultrasound evaluations targeted joints/entheses according to PsASon-Score13 and the most clinically involved joint/enthesis/tendon or the two most clinically involved joints/entheses/tendons (MIJET and 2MIJET).
EClinicalMedicine
December 2024
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Infant alertness and neurologic changes can reflect life-threatening pathology but are assessed by physical exam, which can be intermittent and subjective. Reliable, continuous methods are needed. We hypothesized that our computer vision method to track movement, pose artificial intelligence (AI), could predict neurologic changes in the neonatal intensive care unit (NICU).
View Article and Find Full Text PDFBiosci Microbiota Food Health
September 2024
Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Why patients with symptomatic uncomplicated diverticular disease (SUDD) may develop acute diverticulitis (AD) is still unknown. We analyzed the gut microbiota (GM) in two SUDD patients, one who did experience SUDD recurrence but not AD occurrence (case 1) and one who did experience AD occurrence during follow-up (case 2). The GM of these patients showed differences in terms of phyla (Firmicutes and Bacteroidota in case 1; Actinobacteriota and Proteobacteria in case 2) and subgenera ( and in case 1 and , , , , group, and in case 2).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!